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Soluble interleukin-2 receptor α and interleukin-2 serum levels in patients with basal cell carcinoma.

Authors :
Sobjanek M
Bien E
Zablotna M
Sokolowska-Wojdylo M
Sikorska M
Lange M
Nowicki R
Source :
Postepy dermatologii i alergologii [Postepy Dermatol Alergol] 2016 Aug; Vol. 33 (4), pp. 263-8. Date of Electronic Publication: 2016 Aug 16.
Publication Year :
2016

Abstract

Introduction: Basal cell carcinoma (BCC) is an immunogenic neoplasm and the imbalance in Th1/Th2 cytokines expression seems to play the major role in pathogenesis and clinical behaviour of the tumour.<br />Aim: To investigate the association of soluble interleukin 2α receptor (sIL-2Rα) and interleukin-2 (IL-2) serum concentrations with BCC.<br />Material and Methods: The study involved 110 individuals with BCC and 60 healthy age- and sex-matched volunteers. Serum levels of sIL-2Rα and IL-2 were measured using ELISA test.<br />Results: We found significantly (p = 0.027) increased sIL-2Rα serum levels in BCC patients, in comparison to healthy controls. Statistically (p = 0.04) higher sIL-2Rα levels were observed in patients with more advanced tumours. Serum levels of sIL-2Rα showed a significant linear (r = 0.24, p = 0.018) correlation with tumour size. The average IL-2 serum levels in BCC patients were statistically (p = 0.039) decreased compared to controls. Significantly (p = 0.0454) lower median IL-2 levels were observed in patients with more advanced tumours. A negative correlation between sIL-2Rα and IL-2 serum concentrations was revealed (r = -0.22; p = 0.027).<br />Conclusions: Our results testify to the importance of the IL-2/sIL-2Rα signalling pathway in pathogenesis of BCC, suggesting that IL-2 and sIL-2Rα might be considered as potential markers of disease and targets for immunotherapy in BCC patients.

Details

Language :
English
ISSN :
1642-395X
Volume :
33
Issue :
4
Database :
MEDLINE
Journal :
Postepy dermatologii i alergologii
Publication Type :
Academic Journal
Accession number :
27605896
Full Text :
https://doi.org/10.5114/pdia.2015.55177