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Clinical, radiographic and functional efficacy of abatacept in routine care for rheumatoid arthritis patients: Abatacept Leading Trial for RA on Imaging Remission (ALTAIR) study.
- Source :
-
Clinical and experimental rheumatology [Clin Exp Rheumatol] 2016 Sep-Oct; Vol. 34 (5), pp. 834-841. Date of Electronic Publication: 2016 Aug 31. - Publication Year :
- 2016
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Abstract
- Objectives: To investigate the efficacy and safety of abatacept for treating patients with rheumatoid arthritis (RA) in routine clinical practice and to determine the prognostic factors affecting clinical outcomes.<br />Methods: We performed a retrospective study of 194 RA patients treated with abatacept. Clinical outcomes at 1 year after the treatment were assessed. Joint damage was assessed by the van der Heijde-modified total Sharp score (mTSS).<br />Results: Of the 194 patients, abatacept was discontinued in 51 patients, resulting in a retention rate at week 52 of 73.7%. At week 52, 23.7% of patients achieved clinical remission (SDAI ≤3.3). Lower SDAI and higher RF titre at baseline were the prognostic factor for SDAI at 52 weeks. Structural remission (ΔmTSS ≤0.5) was achieved in 73.4% of patients. However, clinical relevant radiographic progression which was defined as an increase in ΔmTSS >3 in a year, occurred in 7.6% of patients. Likewise, rapid radiological progression, which was defined as an increase in ΔmTSS >5 in a year, was observed in 6.4% of patients. 16.5% of patients achieved comprehensive disease remission, which was defined as SDAI ≤3.3, HAQ-DI ≤0.5, ΔmTSS ≤0.5, while 22.4% of patients achieved comprehensive disease control (CDC), which was defined as SDAI ≤11.0, HAQ-DI ≤0.5, ΔmTSS ≤0.5.<br />Conclusions: The present results confirm that abatacept is effective and safe in routine clinical practice. It is possible that abatacept is more effective in seropositive RA patients with significant immunological abnormality.
- Subjects :
- Abatacept adverse effects
Aged
Antirheumatic Agents adverse effects
Arthritis, Rheumatoid diagnostic imaging
Arthritis, Rheumatoid immunology
Arthritis, Rheumatoid physiopathology
Arthrography
Biomarkers blood
Disease Progression
Female
Health Status
Health Status Indicators
Humans
Japan
Joints diagnostic imaging
Joints immunology
Joints physiopathology
Kaplan-Meier Estimate
Lymphocyte Activation drug effects
Male
Middle Aged
Patient Selection
Predictive Value of Tests
Remission Induction
Retrospective Studies
Serologic Tests
T-Lymphocytes drug effects
T-Lymphocytes immunology
Time Factors
Treatment Outcome
Abatacept therapeutic use
Antirheumatic Agents therapeutic use
Arthritis, Rheumatoid drug therapy
Joints drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0392-856X
- Volume :
- 34
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Clinical and experimental rheumatology
- Publication Type :
- Academic Journal
- Accession number :
- 27607196