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Two Types of Interleukin 17A-Producing γδ T Cells in Protection Against Pulmonary Infection With Klebsiella pneumoniae.
- Source :
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The Journal of infectious diseases [J Infect Dis] 2016 Dec 01; Vol. 214 (11), pp. 1752-1761. Date of Electronic Publication: 2016 Sep 20. - Publication Year :
- 2016
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Abstract
- Background: Klebsiella pneumoniae frequently causes life-threatening infection in children. Interleukin 17A (IL-17A) is known to be involved in protection against K. pneumoniae infection through activation of neutrophils.<br />Methods and Results: We found that IL-17A-producing γδ T cells existed more frequently in younger mice on examination of IL-17A-producing lymphocytes in the lung of naive mice at various ages. We hence compared the protective role of IL-17A-producing γδ T cells against pulmonary K. pneumoniae infection in young (3 weeks old) and adult (8-12 weeks old) mice. IL-17A-deficient mice were susceptible to K. pneumonia regardless of age. Cγ-, Vγ4/6-, or Vδ1-deficient mice were susceptible to K. pneumonia at young age, while interleukin 23p19 (IL-23p19)-deficient mice were susceptible at adult age. IL-17A-producing Vγ1 <superscript>-</superscript> Vγ4 <superscript>-</superscript> γδ T cells expressing canonical Vγ6/Vδ1 genes were dominant over IL-17A-producing Vγ4 <superscript>+</superscript> γδ T cells in the lungs of young mice after infection. The IL-17A-producing Vγ1 <superscript>-</superscript> Vγ4 <superscript>-</superscript> γδ T cells expressed an activation marker, CD69, and proliferated in an IL-23-independent manner, while the IL-17A-producing Vγ4 <superscript>+</superscript> γδ T cells expressing IL-23 receptor but no CD69 proliferated in IL-23-dependent manner.<br />Conclusions: These results suggest that 2 types of IL-17A-producing γδ T cells are activated for host defense against K. pneumoniae infection by IL-23-dependent or independent mechanism.<br /> (© The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.)
Details
- Language :
- English
- ISSN :
- 1537-6613
- Volume :
- 214
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- The Journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 27651419
- Full Text :
- https://doi.org/10.1093/infdis/jiw443