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Evaluation of Xpert MTB/RIF for the Diagnosis of Extrapulmonary Tuberculosis in China.
- Source :
-
Biomedical and environmental sciences : BES [Biomed Environ Sci] 2016 Aug; Vol. 29 (8), pp. 599-602. - Publication Year :
- 2016
-
Abstract
- We evaluate the performance of Xpert MTB/RIF for the diagnosis of extrapulmonary tuberculosis (EPTB) in China. The performance of Xpert was evaluated compared to the composite reference standard (CRS), drug susceptibility testing (DST), and imaging examination. The overall sensitivity and specificity of Xpert were 64.1% (195/304) and 100% (24/24), respectively, using CRS as the gold standard. The sensitivity was significantly higher than that of culture for pus (P<0.05). The proportion of EPTB-positive cases diagnosed by imaging was two times more than that diagnosed using Xpert; however, 6 out of 19 cases may have been overdiagnosed by imaging. Compared to phenotypic DST, the sensitivity and specificity of Xpert were 80% (12/15) and 100% (75/75), respectively. Considering its high sensitivity and specificity, Xpert MTB/RIF may be used as a rapid initial test for EPTB diagnosis, and may also support a quicker decision on the treatment regimen. The combination of imaging and Xpert testing could provide high efficiency and accurate diagnosis of suspected EPTB.<br /> (Copyright © 2016 The Editorial Board of Biomedical and Environmental Sciences. Published by China CDC. All rights reserved.)
- Subjects :
- Bacterial Proteins metabolism
China
DNA-Directed RNA Polymerases metabolism
Diagnostic Tests, Routine instrumentation
Drug Resistance, Bacterial
Humans
Microbial Sensitivity Tests
Mycobacterium tuberculosis genetics
Mycobacterium tuberculosis metabolism
Retrospective Studies
Sensitivity and Specificity
Sputum
Tuberculosis
Bacterial Proteins genetics
DNA-Directed RNA Polymerases genetics
Diagnostic Tests, Routine methods
Mycobacterium tuberculosis drug effects
Mycobacterium tuberculosis isolation & purification
Rifampin pharmacology
Tuberculosis, Pulmonary diagnosis
Tuberculosis, Pulmonary microbiology
Subjects
Details
- Language :
- English
- ISSN :
- 0895-3988
- Volume :
- 29
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Biomedical and environmental sciences : BES
- Publication Type :
- Academic Journal
- Accession number :
- 27660225
- Full Text :
- https://doi.org/10.3967/bes2016.080