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Correlation of HIF-1α/HIF-2α expression with FDG uptake in lung adenocarcinoma.
- Source :
-
Annals of nuclear medicine [Ann Nucl Med] 2016 Dec; Vol. 30 (10), pp. 708-715. Date of Electronic Publication: 2016 Sep 23. - Publication Year :
- 2016
-
Abstract
- Objectives: Hypoxia is a key element involved in the development and progression of tumors. HIF-1α may transiently induce and mediate the response to acute and severe hypoxia, while HIF-2α may induce a longer response and may control the response to chronic and moderate hypoxia. Hypoxia increases the cellular uptake of FDG. Therefore, HIF may play an important role in the process of the cellular uptake of FDG. The aim of this study was to compare HIF-1α/HIF-2α expression with FDG uptake, Glut-1 expression, and prognosis in the patients with lung adenocarcinoma and to investigate the role of HIF-1α/HIF-2α in the uptake of FDG in lung adenocarcinoma.<br />Methods: In the current work, we compared the immunohistochemical expression of HIF-1α and HIF-2α in surgical specimens of 44 patients with lung adenocarcinoma. The relationships between HIF-α expression and Glut-1 expression, FDG uptake, and clinicopathological factors, including prognosis, were analyzed.<br />Results: There was a marginal association between HIF-1α and HIF-2α expressions (P = 0.076). We found a significant correlation between HIF-2α expression and FDG uptake (P = 0.0001). HIF-1α expression showed a marginal association with FDG uptake (P = 0.066). FDG uptake correlated more significantly with HIF-2α expression than with HIF-1α expression. A significant correlation was noticed between Glut-1 expression and both HIF-1α and HIF-2α expressions (P = 0.005 and P = 0.003, respectively). Univariate analysis of disease-free survival demonstrated that FDG uptake and HIF-2α expression, but not HIF-1α expression, were related to recurrence (P < 0.0001).<br />Conclusion: FDG uptake correlated more significantly with HIF-2α expression than with HIF-1α expression, and both FDG uptake and HIF-2α expression, but not HIF-1α expression was correlated with post-operative recurrence in the patients with lung adenocarcinoma. These results suggest that both FDG uptake and HIF-2α expression may represent a more aggressive phenotype and that HIF-2α may play a more important role than HIF-1α in the uptake of FDG in lung adenocarcinoma.
- Subjects :
- Adenocarcinoma diagnosis
Adenocarcinoma pathology
Adenocarcinoma of Lung
Aged
Aged, 80 and over
Biological Transport
Disease-Free Survival
Female
Glucose Transporter Type 1 metabolism
Humans
Lung Neoplasms diagnosis
Lung Neoplasms pathology
Male
Middle Aged
Adenocarcinoma metabolism
Basic Helix-Loop-Helix Transcription Factors metabolism
Fluorodeoxyglucose F18 metabolism
Hypoxia-Inducible Factor 1, alpha Subunit metabolism
Lung Neoplasms metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1864-6433
- Volume :
- 30
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Annals of nuclear medicine
- Publication Type :
- Academic Journal
- Accession number :
- 27663442
- Full Text :
- https://doi.org/10.1007/s12149-016-1116-5