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D-Phenylalanine inhibits biofilm development of a marine microbe, Pseudoalteromonas sp. SC2014.
- Source :
-
FEMS microbiology letters [FEMS Microbiol Lett] 2016 Sep; Vol. 363 (18). Date of Electronic Publication: 2016 Sep 22. - Publication Year :
- 2016
-
Abstract
- D-Amino acids have been reported to be able to inhibit biofilm formation or disperse existing biofilms of many microbes; in some cases this is due to growth inhibition as an unspecific effect. In this work, six different D-amino acids were tested for their inhibitory effects on biofilm development and bacterial growth of Pseudoalteromonas sp. SC2014, a marine microbe involved in microbiologically influenced corrosion (MIC). Experimental results indicated that D-phenylalanine (D-Phe) inhibited biofilm formation effectively at concentrations that did not affect cell growth, whereas the other D-amino acids either showed little effect or inhibited biofilm formation while inhibiting bacterial growth. Further studies found that D-Phe could inhibit bacterial accumulation on the surface of 316L stainless steel, and prevent bacteria from forming a multilayer biofilm. It was also suggested that D-Phe could promote the disassembly of an established multilayer biofilm but have little effect on the remaining monolayer adherent cells. For the first time, it was found that a D-amino acid could effectively inhibit biofilm formation of an MIC-involved microbe. This might supply a new insight into how MIC could be mitigated.<br /> (© FEMS 2016. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Details
- Language :
- English
- ISSN :
- 1574-6968
- Volume :
- 363
- Issue :
- 18
- Database :
- MEDLINE
- Journal :
- FEMS microbiology letters
- Publication Type :
- Academic Journal
- Accession number :
- 27664053
- Full Text :
- https://doi.org/10.1093/femsle/fnw198