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microRNAs target SRSF7 splicing factor to modulate the expression of osteopontin splice variants in renal cancer cells.

Authors :
Boguslawska J
Sokol E
Rybicka B
Czubaty A
Rodzik K
Piekielko-Witkowska A
Source :
Gene [Gene] 2016 Dec 31; Vol. 595 (2), pp. 142-149. Date of Electronic Publication: 2016 Sep 21.
Publication Year :
2016

Abstract

SRSF7 is a SR splicing factor involved in the regulation of splicing and mRNA export of cancer-related genes. The mechanisms regulating the expression of SRSF7 are unknown. This study shows that SRSF7 expression in cancer cells is regulated by microRNAs: short, non-coding RNAs that bind to 3'UTR of target genes and downregulate their expression. We show that microRNAs miR-30a-5p and miR-181a-5p together with SRSF7 form regulatory feedback loop in which the expression of microRNAs is recurrently regulated by its target. Finally, we demonstrate that silencing of SRSF7 affects the expression of osteopontin splice variants and decreases proliferation rate of renal cancer cells.<br /> (Copyright © 2016 Elsevier B.V. All rights reserved.)

Details

Language :
English
ISSN :
1879-0038
Volume :
595
Issue :
2
Database :
MEDLINE
Journal :
Gene
Publication Type :
Academic Journal
Accession number :
27664584
Full Text :
https://doi.org/10.1016/j.gene.2016.09.031