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Recent advances in orally administered cell-specific nanotherapeutics for inflammatory bowel disease.
- Source :
-
World journal of gastroenterology [World J Gastroenterol] 2016 Sep 14; Vol. 22 (34), pp. 7718-26. - Publication Year :
- 2016
-
Abstract
- Inflammatory bowel disease (IBD) is a chronic relapsing disease in gastrointestinal tract. Conventional medications lack the efficacy to offer complete remission in IBD therapy, and usually associate with serious side effects. Recent studies indicated that nanoparticle-based nanotherapeutics may offer precise and safe alternative to conventional medications via enhanced targeting, sustained drug release, and decreased adverse effects. Here, we reviewed orally cell-specific nanotherapeutics developed in recent years. In addition, the various obstacles for oral drug delivery are also reviewed in this manuscript. Orally administrated cell-specific nanotherapeutics is expected to become a novel therapeutic approach for IBD treatment.<br />Competing Interests: Conflict-of-interest statement: The authors declared no conflict of interest related to this study.
- Subjects :
- Animals
Cell Nucleus metabolism
Drug Carriers chemistry
Endosomes metabolism
Epithelium metabolism
Fusion Regulatory Protein-1 chemistry
Galactose chemistry
Gastrointestinal Tract drug effects
Humans
Hyaluronic Acid chemistry
Hydrogels chemistry
Hydrogen-Ion Concentration
Mannose chemistry
Permeability
Reactive Oxygen Species metabolism
Receptors, Transferrin chemistry
Administration, Oral
Inflammatory Bowel Diseases therapy
Nanoparticles chemistry
Pharmaceutical Preparations administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 2219-2840
- Volume :
- 22
- Issue :
- 34
- Database :
- MEDLINE
- Journal :
- World journal of gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 27678353
- Full Text :
- https://doi.org/10.3748/wjg.v22.i34.7718