Back to Search
Start Over
Placental leptin mRNA expression and serum leptin levels in pre-eclampsia associated with HIV infection.
- Source :
-
Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology [J Obstet Gynaecol] 2017 Jan; Vol. 37 (1), pp. 48-52. Date of Electronic Publication: 2016 Oct 03. - Publication Year :
- 2017
-
Abstract
- Leptin, primarily produced by adipocytes, is implicated in the development of pre-eclampsia. This study examines placental leptin production and serum leptin levels in HIV infected and uninfected normotensive and pre-eclamptic pregnancies. Placental leptin production was analysed by RT-PCR and serum leptin levels by ELISA in normotensive (n = 90) and pre-eclamptic (n = 90) pregnancies which were further stratified by HIV status. Placental leptin production was higher in pre-eclampsia compared to normotensive pregnancies irrespective of HIV status (p = .04). Serum leptin was non-significantly raised in HIV uninfected (p = .42) but lower in HIV-infected (p = .03) pre-eclampsia. The latter had lower BMI (p = .007) and triceps skin-fold thickness (p < .001) than the HIV uninfected groups with a significant correlation between serum leptin and triceps skin-fold thickness (p < .001), indicative of less adipose tissue in HIV-infected women with consequently lower serum leptin. Thus, serum leptin levels are not indicative of increased placental production when pre-eclampsia is associated with HIV infection.
- Subjects :
- Adult
Case-Control Studies
Female
HIV Infections blood
HIV Infections complications
Humans
Leptin genetics
Pre-Eclampsia blood
Pre-Eclampsia virology
Pregnancy
Pregnancy Complications, Infectious blood
Pregnancy Complications, Infectious virology
HIV Infections metabolism
Leptin blood
Placenta metabolism
Pre-Eclampsia metabolism
Pregnancy Complications, Infectious metabolism
RNA, Messenger metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1364-6893
- Volume :
- 37
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology
- Publication Type :
- Academic Journal
- Accession number :
- 27690695
- Full Text :
- https://doi.org/10.1080/01443615.2016.1209170