Cervicovaginal Inflammation Facilitates Acquisition of Less Infectious HIV Variants.

Authors :: Selhorst P
Masson L
Ismail SD
Samsunder N
Garrett N
Mansoor LE
Abdool Karim Q
Abdool Karim SS
Passmore JS
Williamson C
Source :: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2017 Jan 01; Vol. 64 (1), pp. 79-82. Date of Electronic Publication: 2016 Sep 29.
Publication Year :: 2017
Abstract: We evaluated whether genital inflammation affects the selection of the transmitted virus. Among South African women, we found that preinfection genital inflammation facilitates transmission of less infectious human immunodeficiency virus, but highly infectious viruses are able to establish infection regardless of inflammation status. This suggests that viral phenotype can influence transmission risk.<br /> (© The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.)

Subjects :: Biomarkers
Cytokines blood
Female
HIV Infections blood
HIV Infections drug therapy
Humans
Phylogeny
Uterine Cervicitis blood
Uterine Cervicitis diagnosis
Vaginitis blood
Vaginitis diagnosis
Viral Load
HIV Infections complications
HIV Infections virology
HIV-1 classification
HIV-1 genetics
Uterine Cervicitis complications
Vaginitis complications

Language :: English
ISSN :: 1537-6591
Volume :: 64
Issue :: 1
Database :: MEDLINE
Journal :: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Publication Type :: Academic Journal
Accession number :: 27694480
Full Text :: https://doi.org/10.1093/cid/ciw663

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