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Exposure to Gestational Diabetes Mellitus: Impact on the Development of Early-Onset Type 2 Diabetes in Canadian First Nations and Non-First Nations Offspring.
- Source :
-
Diabetes care [Diabetes Care] 2016 Dec; Vol. 39 (12), pp. 2240-2246. Date of Electronic Publication: 2016 Oct 04. - Publication Year :
- 2016
-
Abstract
- Objective: Type 2 diabetes is increasing in children worldwide, with Canadian First Nations (FN) children disproportionally affected. The prevalence of gestational diabetes mellitus (GDM) also is increasing. The objective of this study was to evaluate the impact of GDM exposure in utero and FN status on the subsequent risk of type 2 diabetes in offspring in the first 30 years of life.<br />Research Design and Methods: In this population-based historical prospective cohort study, we used administrative databases linked to a clinical database to explore the independent association and interaction between GDM and FN status on the subsequent development of type 2 diabetes in offspring.<br />Results: Among 321,008 births with a median follow-up of 15.1 years, both maternal GDM and FN status were independently associated with subsequent risk of type 2 diabetes in offspring in the first 30 years of life (hazard ratio 3.03 [95% CI 2.44-3.76; P < 0.0001] vs. 4.86 [95% CI 4.08-5.79; P < 0.0001], respectively). No interaction between GDM and FN status on type 2 diabetes risk was observed. FN status had a stronger impact on the development of type 2 diabetes in offspring than GDM.<br />Conclusions: GDM is an important modifiable risk factor for type 2 diabetes, and its prevention may reduce the prevalence of subsequent type 2 diabetes in offspring. This study adds unique and rigorous evidence to the global public health debate about the impact of GDM on the long-term health of offspring.<br /> (© 2016 by the American Diabetes Association.)
- Subjects :
- Adolescent
Adult
Age of Onset
Canada epidemiology
Child
Cohort Studies
Diabetes Mellitus, Type 2 ethnology
Diabetes, Gestational ethnology
Female
Humans
Infant, Newborn
Male
Pregnancy
Prenatal Exposure Delayed Effects ethnology
Prevalence
Prospective Studies
Risk Factors
Young Adult
Diabetes Mellitus, Type 2 epidemiology
Diabetes, Gestational epidemiology
Indians, North American statistics & numerical data
Prenatal Exposure Delayed Effects epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1935-5548
- Volume :
- 39
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Diabetes care
- Publication Type :
- Academic Journal
- Accession number :
- 27703026
- Full Text :
- https://doi.org/10.2337/dc16-1148