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Association of serum calcium and heart failure with preserved ejection fraction in patients with type 2 diabetes.
- Source :
-
Cardiovascular diabetology [Cardiovasc Diabetol] 2016 Oct 03; Vol. 15 (1), pp. 140. Date of Electronic Publication: 2016 Oct 03. - Publication Year :
- 2016
-
Abstract
- Background: Type 2 diabetes mellitus (T2DM) is a recognized trigger factor for heart failure with preserved ejection fraction (HFpEF). Recent studies show that higher serum calcium level is associated with greater risk of both T2DM and heart failure. We speculate that increased serum calcium is related to HFpEF prevalence in patients with T2DM.<br />Methods: In this cross-sectional echocardiographic study, 807 normocalcemia and normophosphatemia patients with T2DM participated, of whom 106 had HFpEF. Multinomial logistic regression was carried out to determine the variables associated with HFpEF. The associations between serum calcium and metabolic parameters, as well as the rate of HFpEF were examined using bivariate linear correlation and binary logistic regression, respectively. The predictive performance of serum calcium for HFpEF was evaluated using the area under the receiver operating characteristic curve (AUC).<br />Results: Patients with HFpEF have significantly higher serum calcium than those without HFpEF. Serum calcium was positively associated with total cholesterol, triglycerides, low-density lipoprotein cholesterol, serum uric acid, HOMA-IR and fasting plasma glucose. Compared with patients in the lowest serum calcium quartile, the odds ratio (OR) for HFpEF in patients in the highest quartile was 2.331 (95 % CI 1.088-4.994, p = 0.029). When calcium was analyzed as a continuous variable, per 1 mg/dL increase, the OR (95 % CI) for HFpEF was [2.712 (1.471-5.002), p = 0.001]. Serum calcium can predict HFpEF [AUC = 0.673, 95 % CI (0.620-0.726), p < 0.001].<br />Conclusions: An increase in serum calcium level is associated with an increased risk of HFpEF in patients with T2DM.
- Subjects :
- Aged
Aged, 80 and over
Area Under Curve
Biomarkers blood
Blood Glucose analysis
China epidemiology
Cross-Sectional Studies
Diabetes Mellitus, Type 2 blood
Diabetes Mellitus, Type 2 diagnosis
Diabetes Mellitus, Type 2 physiopathology
Echocardiography, Doppler
Female
Heart Failure blood
Heart Failure diagnostic imaging
Heart Failure physiopathology
Humans
Insulin Resistance
Linear Models
Lipids blood
Logistic Models
Male
Middle Aged
Multivariate Analysis
Odds Ratio
Predictive Value of Tests
Prevalence
ROC Curve
Risk Factors
Up-Regulation
Uric Acid blood
Calcium blood
Diabetes Mellitus, Type 2 epidemiology
Heart Failure epidemiology
Stroke Volume
Ventricular Function, Left
Subjects
Details
- Language :
- English
- ISSN :
- 1475-2840
- Volume :
- 15
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Cardiovascular diabetology
- Publication Type :
- Academic Journal
- Accession number :
- 27716206
- Full Text :
- https://doi.org/10.1186/s12933-016-0458-6