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Lifetime cancer risk assessment for inhalation exposure to di(2-ethylhexyl) phthalate (DEHP).
- Source :
-
Environmental science and pollution research international [Environ Sci Pollut Res Int] 2017 Jan; Vol. 24 (1), pp. 312-320. Date of Electronic Publication: 2016 Oct 07. - Publication Year :
- 2017
-
Abstract
- The plasticizer di(2-ethylhexyl) phthalate (DEHP) is ubiquitous in the environment and considered as carcinogen; however, the carcinogenic risk of human exposure to DEHP in the air via inhalation is lacking. A probabilistic incremental lifetime cancer risk (ILCR) model was implemented to quantitatively estimate the potential cancer risk of DEHP via human inhalation by using Monte Carlo simulation. We assessed the cancer risk in different age groups (children, adolescents, and adults) exposed to different DEHP concentrations (background low, indoor moderate, and occupational high) for different durations (2, 8, and 20 years). Results showed that the cancer risk of exposure to DEHP was below the acceptable limit (10 <superscript>-6</superscript> ) in the ambient air but was serious in indoor and occupational environments even at short exposure duration (2 years). The cancer risk of DEHP via inhalation in children was lower than that in adolescents and adults, but the risk in children via dermal and oral exposure to indoor dust and soft PVC toys should be considered. Sensitivity analysis indicated that the exposure concentration of DEHP was the strongest factor that influenced ILCR. Our work provides the evidence of cancer risk of DEHP via inhalation and highlights the risk in indoor and occupational environments.
- Subjects :
- Adolescent
Adult
Air Pollutants analysis
Carcinogens analysis
Child
Child, Preschool
Diethylhexyl Phthalate analysis
Female
Humans
Hypersensitivity
Inhalation Exposure adverse effects
Inhalation Exposure statistics & numerical data
Models, Statistical
Monte Carlo Method
Neoplasms epidemiology
Plasticizers analysis
Risk Assessment
Air Pollutants toxicity
Carcinogens toxicity
Diethylhexyl Phthalate toxicity
Dust analysis
Inhalation Exposure analysis
Neoplasms chemically induced
Plasticizers toxicity
Subjects
Details
- Language :
- English
- ISSN :
- 1614-7499
- Volume :
- 24
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Environmental science and pollution research international
- Publication Type :
- Academic Journal
- Accession number :
- 27718112
- Full Text :
- https://doi.org/10.1007/s11356-016-7797-4