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Folate Deficiency Was Associated with Increased Alanine Aminotransferase and Glutamyl Transpeptidase Concentrations in a Chinese Hypertensive Population: A Cross-Sectional Study.
- Source :
-
Journal of nutritional science and vitaminology [J Nutr Sci Vitaminol (Tokyo)] 2016; Vol. 62 (4), pp. 265-271. - Publication Year :
- 2016
-
Abstract
- Alanine aminotransferase (ALT), aspartate transaminase (AST), and glutamyl transpeptidase (GGT) were three key enzymes in the hepatic metabolism. This study aimed to investigate the effect of homocysteine (Hcy) metabolism gene polymorphisms and serum Hcy and folate level on the hepatic functions in a Chinese hypertensive population. A representative sample with 480 subjects aged 28-75 was enrolled in 2005.9-2005.12 from six hospitals in different Chinese regions. Serum ALT, AST and GGT were measured by using an automatic biochemistry analyzer. Serum Hcy was measured by high-performance liquid chromatography, and serum folate was measured by chemiluminescent immunoassay. Known genotypes were detected by PCR-RFLP methods. The results showed that the MTHFR C677T mutation was related a decreased serum AST level (r=-0.11, p=0.026), whereas the MTHFR A1298C mutation elevated serum AST level (r=0.11, p=0.032). Furthermore, multiple regression analysis showed that folate deficiency was associated with higher serum ALT (β (SE): 0.13 (0.06), p=0.031) and GGT level (β (SE): 0.18 (0.07), p=0.011). However, serum Hcy level may not affect the hepatic functions. Our data suggested that hepatic functions were affected by MTHFR gene polymorphisms and serum folate level. Further studies are needed to confirm these correlations in a larger population.
- Subjects :
- Adult
Aged
Aspartate Aminotransferases blood
China
Cross-Sectional Studies
Female
Folic Acid blood
Genotype
Homocysteine blood
Humans
Hypertension genetics
Male
Middle Aged
Polymorphism, Single Nucleotide
Alanine Transaminase blood
Asian People genetics
Folic Acid Deficiency blood
Hypertension blood
Methylenetetrahydrofolate Reductase (NADPH2) genetics
gamma-Glutamyltransferase blood
Subjects
Details
- Language :
- English
- ISSN :
- 1881-7742
- Volume :
- 62
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of nutritional science and vitaminology
- Publication Type :
- Academic Journal
- Accession number :
- 27725412
- Full Text :
- https://doi.org/10.3177/jnsv.62.265