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Effect of superoxide and inflammatory factor on aflatoxin B1 triggered hepatocellular carcinoma.
- Source :
-
American journal of translational research [Am J Transl Res] 2016 Sep 15; Vol. 8 (9), pp. 4003-4008. Date of Electronic Publication: 2016 Sep 15 (Print Publication: 2016). - Publication Year :
- 2016
-
Abstract
- Presently, there have been a lot of documents confirmed that aflatoxin B1 could promote the incident rate of hepato-cellular carcinoma, but the specific mechanism is not completely clear. Some evidences showed that it might relate to oxidative stress and inflammatory reaction. So the rat hepato-cellular carcinoma model was applied in this study for being discussed. Aflatoxin B1 was applied for inducing the rats to produce hepato-cellular carcinoma model to evaluate the expression of histopathology and glutathione transferase. At the same time, we also detected the expression of antioxidase, pro-inflammatory cytokine, proliferating cell nuclear antigen and etc in rat hepato-cellular carcinoma tissues. The histo-pathological results showed that the necrosis of liver cells could be observed after being induced by Aflatoxin B1 for 4 weeks. We could observe obvious hepato-cellular carcinoma in 10 <superscript>th</superscript> week. The level of reactive oxygen species in liver cancer rose obviously, and the activity of antioxidant enzymes reduced. At the same time, the expression level of pro-inflammatory cytokine, TNFα, IL-1α, proliferating cell nuclear antigen and etc all increased significantly. In conclusion, the histological characteristics of hepato-cellular carcinoma could be induced by aflatoxin B1, and the progression of hepato-cellular carcinoma related closely to inflammatory reaction.
Details
- Language :
- English
- ISSN :
- 1943-8141
- Volume :
- 8
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- American journal of translational research
- Publication Type :
- Academic Journal
- Accession number :
- 27725881