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Influence of the Headgroup of Azolium-Based Lipids on Their Biophysical Properties and Cytotoxicity.
- Source :
-
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2017 May 02; Vol. 23 (25), pp. 5920-5924. Date of Electronic Publication: 2016 Nov 10. - Publication Year :
- 2017
-
Abstract
- A series of (un-)charged NHC derivatives bearing two pentadecyl chains in the backbone was studied in detail to find cooperative effects between the membrane and the NHC derivative. The tendency to show lipid-like behavior is dependent on the properties of the NHC derivative headgroup, which can be modified on demand. The surface activity was investigated by film balance measurements, epifluorescence microscopy, and differential scanning calorimetry. Additionally the cytotoxicity was evaluated against different cell lines such as eukaryotic tumor cell lines. These novel lipid-like NHC derivatives offer a broad spectrum for biological applications.<br /> (© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.)
- Subjects :
- 1,2-Dipalmitoylphosphatidylcholine chemistry
Animals
Antineoplastic Agents chemical synthesis
Antineoplastic Agents toxicity
Calorimetry, Differential Scanning
Cell Line
Cell Survival drug effects
Heterocyclic Compounds chemistry
Humans
Liposomes chemical synthesis
Liposomes chemistry
Liposomes toxicity
Methane analogs & derivatives
Methane chemistry
Microscopy, Fluorescence
Antineoplastic Agents chemistry
Lipids chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1521-3765
- Volume :
- 23
- Issue :
- 25
- Database :
- MEDLINE
- Journal :
- Chemistry (Weinheim an der Bergstrasse, Germany)
- Publication Type :
- Academic Journal
- Accession number :
- 27726228
- Full Text :
- https://doi.org/10.1002/chem.201604182