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Cognitive Decline in Relation to Psychological Wellbeing and HIV Disease- and Treatment Characteristics in HIV-Infected Patients on cART: A One-Year Follow-Up Study.
- Source :
-
AIDS and behavior [AIDS Behav] 2017 Jun; Vol. 21 (6), pp. 1728-1734. - Publication Year :
- 2017
-
Abstract
- The objectives of the current study were to examine cognitive decline in relation to psychological wellbeing, HIV disease and treatment characteristics and baseline variables over a one-year period of time in a group of HIV-infected patients on long term cART with undetectable viral load in comparison to a HIV-negative control group. Eighty-two of 95 patients and 43 of 55 controls who completed a baseline assessment for the Art-NeCo study underwent a follow-up neuropsychological assessment. A repeated-measure general linear model analysis was performed to compare the performance at follow-up in comparison to baseline between the patients and controls. Reliable change indices were computed as a measure of significant change in cognitive function. Compared to controls, patients overall performed worse on the domain speed of information processing. In the patient group a worse performance at follow-up was present for the verbal fluency domain compared to the controls, in the absence of a baseline group difference. For the executive function domain, no group differences were found at follow-up, but the patients performed worse than the controls at baseline. We found that cognitive decline was related to more frequent use of recreational drugs and a somewhat heightened level of irritability and more somatic complaints at baseline. However, the decliners did not differ from the non-decliners on any of the HIV-related variables.
- Subjects :
- Adult
Cognition
Cognitive Dysfunction
Female
Follow-Up Studies
HIV Infections virology
HIV-1
Humans
Male
Middle Aged
Neuropsychological Tests
Quality of Life
Viral Load
Anti-Retroviral Agents therapeutic use
Antiretroviral Therapy, Highly Active
Executive Function drug effects
HIV Infections drug therapy
HIV Infections psychology
Subjects
Details
- Language :
- English
- ISSN :
- 1573-3254
- Volume :
- 21
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- AIDS and behavior
- Publication Type :
- Academic Journal
- Accession number :
- 27752871
- Full Text :
- https://doi.org/10.1007/s10461-016-1583-7