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Synergistic effect of anidulafungin combined with posaconazole in experimental aspergillosis.
- Source :
-
Medical mycology [Med Mycol] 2017 Jun 01; Vol. 55 (4), pp. 457-460. - Publication Year :
- 2017
-
Abstract
- Clinical and experimental data have shown discrepancies on the efficacy of combinations between triazoles and echinocandins. In this study, anidulafungin plus posaconazole have shown efficacy against a murine systemic infection by three strains of Aspergillus fumigatus. The combination increased mice survival and reduced burden in the kidneys over the corresponding monotherapies and voriconazole. Clearance of kidneys was observed in 62% to 100% of animals (strain dependant). We observed good in vitro- in vivo correlation when a cutoff < 1 was indicative of synergy. Our results showed that the combination could be a therapeutical option, especially against infections refractory to the first line therapy.<br /> (© The Author 2016. Published by Oxford University Press on behalf of The International Society for Human and Animal Mycology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
- Subjects :
- Anidulafungin
Animals
Antifungal Agents pharmacology
Aspergillus fumigatus isolation & purification
Disease Models, Animal
Drug Therapy, Combination
Echinocandins pharmacology
Kidney microbiology
Male
Mice
Survival Analysis
Triazoles pharmacology
Antifungal Agents administration & dosage
Aspergillosis drug therapy
Aspergillus fumigatus drug effects
Drug Synergism
Echinocandins administration & dosage
Triazoles administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1460-2709
- Volume :
- 55
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Medical mycology
- Publication Type :
- Academic Journal
- Accession number :
- 27760829
- Full Text :
- https://doi.org/10.1093/mmy/myw110