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Entamoeba Encystation: New Targets to Prevent the Transmission of Amebiasis.
- Source :
-
PLoS pathogens [PLoS Pathog] 2016 Oct 20; Vol. 12 (10), pp. e1005845. Date of Electronic Publication: 2016 Oct 20 (Print Publication: 2016). - Publication Year :
- 2016
-
Abstract
- Amebiasis is caused by Entamoeba histolytica infection and can produce a broad range of clinical signs, from asymptomatic cases to patients with obvious symptoms. The current epidemiological and clinical statuses of amebiasis make it a serious public health problem worldwide. The Entamoeba life cycle consists of the trophozoite, the causative agent for amebiasis, and the cyst, the form responsible for transmission. These two stages are connected by "encystation" and "excystation." Hence, developing novel strategies to control encystation and excystation will potentially lead to new measures to block the transmission of amebiasis by interrupting the life cycle of the causative agent. Here, we highlight studies investigating encystation using inhibitory chemicals and categorize them based on the molecules inhibited. We also present a perspective on new strategies to prevent the transmission of amebiasis.<br />Competing Interests: The authors have declared that no competing interests exist.
- Subjects :
- Humans
Amebiasis transmission
Entamoeba
Subjects
Details
- Language :
- English
- ISSN :
- 1553-7374
- Volume :
- 12
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- PLoS pathogens
- Publication Type :
- Academic Journal
- Accession number :
- 27764256
- Full Text :
- https://doi.org/10.1371/journal.ppat.1005845