Gonadal dysgenesis in disorders of sex development: Diagnosis and surgical management.

Authors :: Wolffenbuttel KP
Hersmus R
Stoop H
Biermann K
Hoebeke P
Cools M
Looijenga LH
Source :: Journal of pediatric urology [J Pediatr Urol] 2016 Dec; Vol. 12 (6), pp. 411-416. Date of Electronic Publication: 2016 Oct 08.
Publication Year :: 2016
Abstract: Recent studies on gonadal histology have improved the understanding of germ cell malignancy risk in patients with disorders of sex development (DSD), and evidence-based gonadal management strategies are gradually emerging. Especially in 46,XY DSD and 45,X/46,XY DSD, which are characterized by gonadal dysgenesis, the risk of germ cell malignancy is significantly increased. This paper summarized the progress over the past 10 years in malignancy risk assessment in patients with DSD, and its implications for optimal surgical handling of the involved gonads.<br /> (Copyright © 2016 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved.)

Subjects :: Child
Decision Trees
Female
Humans
Male
Urologic Surgical Procedures methods
Gonadal Dysgenesis diagnosis
Gonadal Dysgenesis surgery

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