Back to Search
Start Over
Synthesis and antimalarial activity of N-benzylated (N-arylcarbamoyl)alkylphosphonic acid derivatives.
- Source :
-
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2016 Dec 01; Vol. 24 (23), pp. 6131-6138. Date of Electronic Publication: 2016 Apr 09. - Publication Year :
- 2016
-
Abstract
- A series of novel and readily accessible N-benzylated (N-arylcarbamoyl)alkylphosphonate esters and related compounds have been prepared as potential antimalarial agents. Bioassays reveal that some of these compounds exhibit promising activity against Plasmodium falciparum, and exhibit no significant growth inhibition of HeLa cells.<br /> (Copyright © 2016. Published by Elsevier Ltd.)
- Subjects :
- Aldose-Ketose Isomerases antagonists & inhibitors
Amides chemical synthesis
Amides toxicity
Antimalarials chemical synthesis
Antimalarials toxicity
Fosfomycin analogs & derivatives
Fosfomycin pharmacology
HeLa Cells
Humans
Organophosphonates chemical synthesis
Organophosphonates toxicity
Plasmodium falciparum drug effects
Structure-Activity Relationship
Amides pharmacology
Antimalarials pharmacology
Organophosphonates pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1464-3391
- Volume :
- 24
- Issue :
- 23
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 27773366
- Full Text :
- https://doi.org/10.1016/j.bmc.2016.04.021