Back to Search
Start Over
Targeting NO/cGMP Signaling in the CNS for Neurodegeneration and Alzheimer's Disease.
- Source :
-
Current medicinal chemistry [Curr Med Chem] 2016; Vol. 23 (24), pp. 2770-2788. - Publication Year :
- 2016
-
Abstract
- cAMP-response element-binding protein (CREB) plays a central role in various aspects of central nervous system (CNS) function, ranging from the developmental stages to neuronal plasticity and survival in adult brain. Activation of CREB plays a crucial role in learning and memory and is at the convergence of multiple intracellular signaling cascades including CAMKII and MAPK. This review focuses on the important functions of nitric oxide (NO) in activating CREB via the NO receptor, soluble guanylyl cyclase (sGC), and production of the second messenger, cGMP. The involvement of the NO/cGMP signaling pathway in synaptic plasticity suggests several avenues for therapeutic intervention, and targeting early synaptic degeneration could be an attractive approach for the development of novel disease-modifying approaches to treat cognition and memory dysfunction in neurodegenerative diseases.
- Subjects :
- Alzheimer Disease metabolism
CREB-Binding Protein metabolism
Humans
Neurodegenerative Diseases metabolism
Neuronal Plasticity physiology
Phosphoric Diester Hydrolases chemistry
Phosphoric Diester Hydrolases metabolism
Signal Transduction
Soluble Guanylyl Cyclase antagonists & inhibitors
Soluble Guanylyl Cyclase metabolism
Synapses metabolism
Alzheimer Disease pathology
Central Nervous System metabolism
Cyclic GMP metabolism
Neurodegenerative Diseases pathology
Nitric Oxide metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1875-533X
- Volume :
- 23
- Issue :
- 24
- Database :
- MEDLINE
- Journal :
- Current medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 27776476
- Full Text :
- https://doi.org/10.2174/0929867323666160812145454