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RNAs as chaperones.

Authors :
Horowitz S
Bardwell JC
Source :
RNA biology [RNA Biol] 2016 Dec; Vol. 13 (12), pp. 1228-1231. Date of Electronic Publication: 2016 Oct 28.
Publication Year :
2016

Abstract

Recently, we found that RNA is a remarkably powerful chaperone that can bind to unfolded proteins and transfer them to Hsp70 for refolding. Combined with past studies on RNA-chaperone interactions, we propose a model for how chaperone RNA activity may contribute to the cellular response to stress.

Subjects

Subjects :
Models, Molecular
Molecular Chaperones metabolism
Protein Folding
Proteins metabolism
Stress, Physiological
HSP70 Heat-Shock Proteins metabolism
Proteins chemistry
RNA metabolism

Details

Language :
English
ISSN :
1555-8584
Volume :
13
Issue :
12
Database :
MEDLINE
Journal :
RNA biology
Publication Type :
Academic Journal
Accession number :
27791471
Full Text :
https://doi.org/10.1080/15476286.2016.1247147
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