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Effects of Oxandrolone on Cardiometabolic Health in Boys With Klinefelter Syndrome: A Randomized Controlled Trial.

Authors :
Davis SM
Cox-Martin MG
Bardsley MZ
Kowal K
Zeitler PS
Ross JL
Source :
The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2017 Jan 01; Vol. 102 (1), pp. 176-184.
Publication Year :
2017

Abstract

Context: Klinefelter syndrome (KS) is a common condition in males, resulting in androgen deficiency and cardiometabolic diseases. These interrelated conditions may be present in prepubertal boys with KS.<br />Objective: To determine whether supplemental low-dose androgen has a beneficial effect on body composition in prepubertal boys with KS.<br />Design, Setting, and Participants: We conducted a secondary analysis of a randomized, double-blind, placebo-controlled clinical trial in 93 boys with KS aged 4 to 12 years.<br />Interventions: Oral oxandrolone (Ox) 0.06 mg/kg/d or placebo for 2 years.<br />Outcome Measures: The primary outcome was percent body fat standard deviation score (%BF SDS) at 2 years. Secondary outcomes included additional measures of cardiometabolic health and safety.<br />Results: The %BF SDS at 2 years was significantly lower in the treatment (0.29 ± 0.76 SDS) compared with placebo group (0.81 ± 0.72 SDS) after adjusting for age and baseline %BF SDS (95% confidence interval for the difference between means -0.86 to -0.19 SDS, P = 0.009). Ox resulted in lower triglycerides (P = 0.043), but also lower high-density lipoprotein (HDL) cholesterol (P < 0.001) and a more rapid advancement in bone age (P = 0.011).<br />Conclusions: Ox has positive effects on measures of cardiometabolic health in prepubertal boys with KS; however, it does lower HDL cholesterol and advance bone age.<br /> (Copyright © 2017 by the Endocrine Society)

Details

Language :
English
ISSN :
1945-7197
Volume :
102
Issue :
1
Database :
MEDLINE
Journal :
The Journal of clinical endocrinology and metabolism
Publication Type :
Academic Journal
Accession number :
27802097
Full Text :
https://doi.org/10.1210/jc.2016-2904