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The Acute-on-Chronic Liver Failure Syndrome, or When the Innate Immune System Goes Astray.
- Source :
-
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2016 Nov 15; Vol. 197 (10), pp. 3755-3761. - Publication Year :
- 2016
-
Abstract
- The acute-on-chronic liver failure (ACLF) syndrome is characterized by acute decompensation of cirrhosis, organ failure, and high 28-d mortality. ACLF displays key features of systemic inflammation and its poor outcome is closely associated with exacerbated systemic inflammatory responses. In this review, we describe the prevailing characteristics of systemic inflammation in patients with decompensated cirrhosis and ACLF, with special emphasis on the principal features of the cytokine storm the mechanisms underlying this intense systemic inflammatory response (i.e., presence of circulating pathogen- and damage-associated molecular patterns), and their implication in tissue and organ damage in this condition.<br /> (Copyright © 2016 by The American Association of Immunologists, Inc.)
- Subjects :
- Acute-On-Chronic Liver Failure complications
Acute-On-Chronic Liver Failure mortality
Humans
Inflammation complications
Inflammation immunology
Liver Cirrhosis immunology
Liver Cirrhosis physiopathology
Prognosis
Prospective Studies
Severity of Illness Index
Acute-On-Chronic Liver Failure immunology
Acute-On-Chronic Liver Failure physiopathology
Cytokines immunology
Immunity, Innate immunology
Inflammation physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1550-6606
- Volume :
- 197
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Journal of immunology (Baltimore, Md. : 1950)
- Publication Type :
- Academic Journal
- Accession number :
- 27815438
- Full Text :
- https://doi.org/10.4049/jimmunol.1600818