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Visualizing GPCR 'Megaplexes' Which Enable Sustained Intracellular Signaling.
- Source :
-
Trends in biochemical sciences [Trends Biochem Sci] 2016 Dec; Vol. 41 (12), pp. 985-986. Date of Electronic Publication: 2016 Nov 04. - Publication Year :
- 2016
-
Abstract
- A range of cutting-edge techniques have been employed to visualize 'megaplexes' consisting of a G protein-coupled receptor (GPCR) bound to β-arrestin in intracellular endosomes following agonist-induced internalization. Surprisingly, the complex includes simultaneous binding of the heterotrimeric G protein, which retains full functional activity and supports sustained signaling from within the cell.<br /> (Copyright © 2016 Elsevier Ltd. All rights reserved.)
- Subjects :
- Adrenergic beta-2 Receptor Agonists pharmacology
Adrenergic beta-2 Receptor Antagonists pharmacology
Bioluminescence Resonance Energy Transfer Techniques
Biosensing Techniques methods
Deamino Arginine Vasopressin pharmacology
Endosomes drug effects
Endosomes metabolism
Fluorescence Resonance Energy Transfer
Gene Expression Regulation
HEK293 Cells
Humans
Isoproterenol pharmacology
Models, Molecular
Molecular Probes chemistry
Propanolamines pharmacology
Protein Binding
Receptors, Adrenergic, beta-2 chemistry
Receptors, Adrenergic, beta-2 genetics
Receptors, Vasopressin chemistry
Receptors, Vasopressin genetics
Recombinant Fusion Proteins chemistry
Recombinant Fusion Proteins genetics
Recombinant Fusion Proteins metabolism
beta-Arrestin 1 chemistry
beta-Arrestin 1 genetics
Cyclic AMP biosynthesis
Receptors, Adrenergic, beta-2 metabolism
Receptors, Vasopressin metabolism
Signal Transduction
beta-Arrestin 1 metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0968-0004
- Volume :
- 41
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Trends in biochemical sciences
- Publication Type :
- Academic Journal
- Accession number :
- 27825513
- Full Text :
- https://doi.org/10.1016/j.tibs.2016.10.006