Receptor for Advanced Glycation End Products Regulates Leukotriene B 4 Receptor 1 Signaling.

Leukotriene B ₄ receptor 1 (BLT1), a high-affinity G protein-coupled receptor (GPCR) for leukotriene B ₄ (LTB ₄ ), plays important roles in inflammatory and immune reactions. Although the LTB ₄ -BLT1 axis is known to promote inflammation, the binding proteins that modulate LTB ₄ -BLT1 signaling have not been identified. Recently, we discovered that receptor for advanced glycation end products (RAGE) interacts with BLT1 and modulates LTB ₄ -BLT1 signaling. We propose RAGE as a new class of GPCR modulator and a new target of future GPCR studies.