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Gadolinium hybrid iron oxide nanocomposites for dual T 1 - and T 2 -weighted MR imaging of cell labeling.
- Source :
-
Biomaterials science [Biomater Sci] 2016 Dec 20; Vol. 5 (1), pp. 50-56. - Publication Year :
- 2016
-
Abstract
- Tracking of cells in biological systems is critically important for monitoring disease treatment, such as in stem cell therapy. This report prepared new types of biocompatible gadolinium hybrid iron oxide (GdIO) nanocomposites, which demonstrated high sensitivity for dual T <subscript>1</subscript> - and T <subscript>2</subscript> -weighted magnetic resonance imaging (MRI). The GdIO nanocomposites could efficiently label mesenchymal stem cells (MSCs) by incubation for 24 h at a safe dose, as they did not affect the cell viability, proliferation or differentiation capacity. There was high contrast enhancement in the GdIO-labeled stem cells for dual T <subscript>1</subscript> - and T <subscript>2</subscript> -weighted MR imaging. In addition, the GdIO nanocomposites were injected into adult mouse lateral ventricles, where cells could be labeled to monitor their biological behaviors by MRI. These GdIO nanocomposites with dual-imaging functions are a good platform for cell labeling and other diagnostic applications.
- Subjects :
- Animals
Contrast Media
Ferric Compounds toxicity
Gadolinium toxicity
Mesenchymal Stem Cells drug effects
Mesenchymal Stem Cells metabolism
Mice
Nanocomposites toxicity
Staining and Labeling
Ferric Compounds chemistry
Gadolinium chemistry
Magnetic Resonance Imaging methods
Nanocomposites chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 2047-4849
- Volume :
- 5
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Biomaterials science
- Publication Type :
- Academic Journal
- Accession number :
- 27840861
- Full Text :
- https://doi.org/10.1039/c6bm00706f