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Noncoding RNAs as novel biomarkers in pancreatic cancer: what do we know?
- Source :
-
Future oncology (London, England) [Future Oncol] 2017 Feb; Vol. 13 (5), pp. 443-453. Date of Electronic Publication: 2016 Nov 14. - Publication Year :
- 2017
-
Abstract
- Pancreatic cancer is an aggressive cancer of the digestive system, which is becoming a serious health problem worldwide. Overall survival for patients with pancreatic cancer is poor, mainly due to a lack of biomarkers to enable early diagnosis and a lack of prognostic markers that can inform decision-making, facilitating personalized treatment and an optimal clinical outcome. ncRNAs play an important role in pancreatic carcinogenesis. Here we review the literature on the role of ncRNAs as biomarkers in pancreatic cancer. We focus on the significance of ncRNAs as markers for early diagnosis, as prognostic biomarkers able to inform clinical management and as targets for novel therapeutics for patients with pancreatic cancer.<br />Competing Interests: Financial & competing interests diclosure C Braconi is currently funded by an Institute of Cancer Research Clinician-Scientist Fellowship, a Marie Curie Career Integration Grant (EU), a Research Innovation Fund by Pancreatic Cancer UK, an Early Diagnosis Challenge Award from Pancreatic Cancer Action and a project grant from NIHR/BRC at the Royal Marsden/Institute of Cancer Research. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.
- Subjects :
- Adenocarcinoma genetics
Genetic Therapy
Humans
MicroRNAs genetics
Pancreatic Neoplasms diagnosis
Pancreatic Neoplasms mortality
Pancreatic Neoplasms therapy
Prognosis
RNA, Long Noncoding
RNA, Messenger
Biomarkers, Tumor
Gene Expression Regulation, Neoplastic
Pancreatic Neoplasms genetics
RNA, Untranslated
Subjects
Details
- Language :
- English
- ISSN :
- 1744-8301
- Volume :
- 13
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Future oncology (London, England)
- Publication Type :
- Academic Journal
- Accession number :
- 27841659
- Full Text :
- https://doi.org/10.2217/fon-2016-0253