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Accuracy and cost-effectiveness of dynamic contrast-enhanced CT in the characterisation of solitary pulmonary nodules-the SPUtNIk study.
- Source :
-
BMJ open respiratory research [BMJ Open Respir Res] 2016 Oct 14; Vol. 3 (1), pp. e000156. Date of Electronic Publication: 2016 Oct 14 (Print Publication: 2016). - Publication Year :
- 2016
-
Abstract
- Introduction: Solitary pulmonary nodules (SPNs) are common on CT. The most cost-effective investigation algorithm is still to be determined. Dynamic contrast-enhanced CT (DCE-CT) is an established diagnostic test not widely available in the UK currently.<br />Methods and Analysis: The SPUtNIk study will assess the diagnostic accuracy, clinical utility and cost-effectiveness of DCE-CT, alongside the current CT and 18-flurodeoxyglucose-positron emission tomography) ( <superscript>18</superscript> FDG-PET)-CT nodule characterisation strategies in the National Health Service (NHS). Image acquisition and data analysis for <superscript>18</superscript> FDG-PET-CT and DCE-CT will follow a standardised protocol with central review of 10% to ensure quality assurance. Decision analytic modelling will assess the likely costs and health outcomes resulting from incorporation of DCE-CT into management strategies for patients with SPNs.<br />Ethics and Dissemination: Approval has been granted by the South West Research Ethics Committee. Ethics reference number 12/SW/0206. The results of the trial will be presented at national and international meetings and published in an Health Technology Assessment (HTA) Monograph and in peer-reviewed journals.<br />Trial Registration Number: ISRCTN30784948; Pre-results.<br />Competing Interests: Conflicts of Interest: None declared.
Details
- Language :
- English
- ISSN :
- 2052-4439
- Volume :
- 3
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- BMJ open respiratory research
- Publication Type :
- Academic Journal
- Accession number :
- 27843550
- Full Text :
- https://doi.org/10.1136/bmjresp-2016-000156