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Accuracy and cost-effectiveness of dynamic contrast-enhanced CT in the characterisation of solitary pulmonary nodules-the SPUtNIk study.

Authors :
Qureshi NR
Rintoul RC
Miles KA
George S
Harris S
Madden J
Cozens K
Little LA
Eichhorst K
Jones J
Moate P
McClement C
Pike L
Sinclair D
Wong WL
Shekhdar J
Eaton R
Shah A
Brindle L
Peebles C
Banerjee A
Dizdarevic S
Han S
Poon FW
Groves AM
Kurban L
Frew AJ
Callister ME
Crosbie P
Gleeson FV
Karunasaagarar K
Kankam O
Gilbert FJ
Source :
BMJ open respiratory research [BMJ Open Respir Res] 2016 Oct 14; Vol. 3 (1), pp. e000156. Date of Electronic Publication: 2016 Oct 14 (Print Publication: 2016).
Publication Year :
2016

Abstract

Introduction: Solitary pulmonary nodules (SPNs) are common on CT. The most cost-effective investigation algorithm is still to be determined. Dynamic contrast-enhanced CT (DCE-CT) is an established diagnostic test not widely available in the UK currently.<br />Methods and Analysis: The SPUtNIk study will assess the diagnostic accuracy, clinical utility and cost-effectiveness of DCE-CT, alongside the current CT and 18-flurodeoxyglucose-positron emission tomography) ( <superscript>18</superscript> FDG-PET)-CT nodule characterisation strategies in the National Health Service (NHS). Image acquisition and data analysis for <superscript>18</superscript> FDG-PET-CT and DCE-CT will follow a standardised protocol with central review of 10% to ensure quality assurance. Decision analytic modelling will assess the likely costs and health outcomes resulting from incorporation of DCE-CT into management strategies for patients with SPNs.<br />Ethics and Dissemination: Approval has been granted by the South West Research Ethics Committee. Ethics reference number 12/SW/0206. The results of the trial will be presented at national and international meetings and published in an Health Technology Assessment (HTA) Monograph and in peer-reviewed journals.<br />Trial Registration Number: ISRCTN30784948; Pre-results.<br />Competing Interests: Conflicts of Interest: None declared.

Details

Language :
English
ISSN :
2052-4439
Volume :
3
Issue :
1
Database :
MEDLINE
Journal :
BMJ open respiratory research
Publication Type :
Academic Journal
Accession number :
27843550
Full Text :
https://doi.org/10.1136/bmjresp-2016-000156