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Prediagnostic alcohol consumption and colorectal cancer survival: The Colon Cancer Family Registry.
- Source :
-
Cancer [Cancer] 2017 May 15; Vol. 123 (6), pp. 1035-1043. Date of Electronic Publication: 2016 Nov 08. - Publication Year :
- 2017
-
Abstract
- Background: Although previous studies have noted an increased risk of colorectal cancer (CRC) among moderate to heavy alcohol consumers in comparison with nondrinkers, the relation between alcohol consumption and CRC survival remains unclear.<br />Methods: Cases of incident invasive CRC diagnosed between 1997 and 2007 were identified via population-based cancer registries at 4 study sites in the Colon Cancer Family Registry. Study participants completed a risk-factor questionnaire on prediagnostic behaviors, including wine, beer, and liquor consumption, at the baseline. Prospective follow-up for survival was conducted for 4966 CRC cases. Cox regression was used to compare nondrinkers with individuals who consumed, on average, 1 or more servings of alcohol per day in the years preceding their CRC diagnosis with respect to overall and disease-specific survival. Separate analyses by beverage type, stratified by patient and tumor attributes, were also performed. All models were adjusted for the age at diagnosis, sex, study site, year of diagnosis, smoking history, body mass index, and education.<br />Results: Prediagnostic beer and liquor consumption was not associated with CRC survival; however, higher levels of wine consumption were modestly associated with a better prognosis overall (CRC-specific hazard ratio [HR], 0.70, 95% confidence interval [CI], 0.48-1.03; overall HR, 0.70; 95% CI, 0.53-0.94). Similar patterns were noted in stratified analyses.<br />Conclusions: These findings suggest that prediagnostic wine consumption is modestly associated with more favorable survival after CRC. Cancer 2017;123:1035-43. © 2016 American Cancer Society.<br /> (© 2016 American Cancer Society.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Colorectal Neoplasms diagnosis
Colorectal Neoplasms etiology
Colorectal Neoplasms mortality
Female
Humans
Male
Middle Aged
Population Surveillance
Prognosis
Registries
Risk Factors
Smoking adverse effects
Surveys and Questionnaires
Survival Analysis
Young Adult
Alcohol Drinking adverse effects
Colorectal Neoplasms epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1097-0142
- Volume :
- 123
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 27861761
- Full Text :
- https://doi.org/10.1002/cncr.30446