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Copper is a Cofactor of the Formylglycine-Generating Enzyme.
- Source :
-
Chembiochem : a European journal of chemical biology [Chembiochem] 2017 Jan 17; Vol. 18 (2), pp. 161-165. Date of Electronic Publication: 2016 Dec 13. - Publication Year :
- 2017
-
Abstract
- Formylglycine-generating enzyme (FGE) is an O <subscript>2</subscript> -utilizing oxidase that converts specific cysteine residues of client proteins to formylglycine. We show that Cu <superscript>I</superscript> is an integral cofactor of this enzyme and binds with high affinity (K <subscript>D</subscript> =of 10 <superscript>-17</superscript> m) to a pair of active-site cysteines. These findings establish FGE as a novel type of copper enzyme.<br /> (© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.)
- Subjects :
- Actinobacteria enzymology
Biocatalysis
Catalytic Domain
Copper chemistry
Cysteine chemistry
Cysteine metabolism
Electron Spin Resonance Spectroscopy
Glycine chemistry
Glycine metabolism
Humans
Kinetics
Molecular Dynamics Simulation
Sulfatases chemistry
Copper metabolism
Glycine analogs & derivatives
Sulfatases metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1439-7633
- Volume :
- 18
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Chembiochem : a European journal of chemical biology
- Publication Type :
- Academic Journal
- Accession number :
- 27862795
- Full Text :
- https://doi.org/10.1002/cbic.201600359