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Association of tryptophan hydroxylase-2 polymorphisms with oppositional defiant disorder in a Chinese Han population.
- Source :
-
Behavioral and brain functions : BBF [Behav Brain Funct] 2016 Nov 21; Vol. 12 (1), pp. 30. Date of Electronic Publication: 2016 Nov 21. - Publication Year :
- 2016
-
Abstract
- Background: Oppositional defiant disorder (ODD) is a behavioral disorder of school-age population. It is well known that 5-HT dysfunction is correlated with impulsivity, which is one of the common characteristics of ODD. The enzyme tryptophan hydroxylase-2 (TPH-2) synthesizes 5-HT in serotonergic neurons of the midbrain raphe. The purposes of this study were to investigate the potential association of TPH-2 polymorphisms with susceptibility to ODD in a Han Chinese school population.<br />Methods: Four polymorphisms (rs4570625, rs11178997, rs1386494 and rs7305115) of the TPH-2 gene were analyzed by using polymerase chain reaction and DNA microarray hybridization in a case-control study of 276 Han Chinese individuals (124 ODD and 152 controls).<br />Results: In single marker analyses,there was a significant difference in the genotype (χ <superscript>2</superscript>  = 4.163, P = 0.041) and allele frequency (χ <superscript>2</superscript>  = 3.930, P = 0.047) of rs1386494 between ODD and control groups. Haplotype analyses revealed higher frequencies of haplotypes TA (rs4570625-rs11178997), TAG (rs4570625-rs11178997-rs1386494), TAA (rs4570625-rs11178997-rs7305115) and TAGA (rs4570625-rs11178997-rs1386494-rs7305115), but lower frequencies of haplotypes GA (rs4570625-rs11178997) and GAG (rs4570625-rs11178997-rs1386494) in ODD compared to control groups.<br />Conclusions: These findings suggest the role of these TPH-2 gene variants in susceptibility to ODD. Some haplotypes might be the risk factors for Chinese Han children with ODD, while others might be preventable factors.
- Subjects :
- Adolescent
Asian People genetics
Case-Control Studies
Child
China
Ethnicity genetics
Female
Gene Frequency
Genetic Association Studies methods
Genetic Predisposition to Disease
Haplotypes
Humans
Linkage Disequilibrium
Male
Polymorphism, Single Nucleotide
Tryptophan Hydroxylase metabolism
Attention Deficit and Disruptive Behavior Disorders enzymology
Attention Deficit and Disruptive Behavior Disorders genetics
Tryptophan Hydroxylase genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1744-9081
- Volume :
- 12
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Behavioral and brain functions : BBF
- Publication Type :
- Academic Journal
- Accession number :
- 27871272
- Full Text :
- https://doi.org/10.1186/s12993-016-0113-0