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Molecular mechanisms of PFOA-induced toxicity in animals and humans: Implications for health risks.
- Source :
-
Environment international [Environ Int] 2017 Feb; Vol. 99, pp. 43-54. Date of Electronic Publication: 2016 Nov 18. - Publication Year :
- 2017
-
Abstract
- As an emerging persistent organic pollutant (POP), perfluorooctanoate (PFOA) is one of the most abundant perfluorinated compounds (PFCs) in the environment. This review summarized the molecular mechanisms and signaling pathways of PFOA-induced toxicity in animals and humans as well as their implications for health risks in humans. Traditional PFOA-induced signal pathways such as peroxisome proliferating receptor alpha (PPARα), constitutive androstane receptor (CAR), farnesoid X receptor (FXR), and pregnane-X receptor (PXR) may not be important for PFOA-induced health effects on humans. Instead, pathways including p53/mitochondrial pathway, nuclear lipid hyperaccumulation, phosphatidylinositol 3-kinase-serine/threonine protein kinase (PI3K-AKT), and tumor necrosis factor-α/nuclear factor κB (TNF-α/NF-κB) may play an important role for PFOA-induced health risks in humans. Both in vivo and in vitro studies are needed to better understand the PFOA-induced toxicity mechanisms as well as the associated health risk in humans.<br /> (Published by Elsevier Ltd.)
Details
- Language :
- English
- ISSN :
- 1873-6750
- Volume :
- 99
- Database :
- MEDLINE
- Journal :
- Environment international
- Publication Type :
- Academic Journal
- Accession number :
- 27871799
- Full Text :
- https://doi.org/10.1016/j.envint.2016.11.014