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Inhibition of infectivity of human immunodeficiency virus by a novel nucleoside, oxetanocin, and related compounds.
- Source :
-
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 1989 May; Vol. 33 (5), pp. 773-5. - Publication Year :
- 1989
-
Abstract
- Oxetanocin is a novel nucleoside containing a 4-membered sugar, oxetanosyl-N-glycoside, and adenine. The effects of oxetanocin and related compounds on the infectivity of human immunodeficiency virus (HIV) were examined. They inhibited HIV infectivity in vitro. Allopurinol and mycophenolic acid produced additive anti-HIV effects when added with these compounds.
- Subjects :
- Adenine analysis
Adenine pharmacology
Allopurinol pharmacology
Anti-Bacterial Agents analysis
Cells, Cultured
Chromatography, High Pressure Liquid
HIV drug effects
Humans
In Vitro Techniques
Mycophenolic Acid pharmacology
T-Lymphocytes drug effects
Adenine analogs & derivatives
Anti-Bacterial Agents pharmacology
HIV pathogenicity
Subjects
Details
- Language :
- English
- ISSN :
- 0066-4804
- Volume :
- 33
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Antimicrobial agents and chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 2787618
- Full Text :
- https://doi.org/10.1128/AAC.33.5.773