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4-hydroxynonenal-mediated signaling and aging.
- Source :
-
Free radical biology & medicine [Free Radic Biol Med] 2017 Oct; Vol. 111, pp. 219-225. Date of Electronic Publication: 2016 Nov 20. - Publication Year :
- 2017
-
Abstract
- 4-Hydroxy-2-nonenal (HNE), one of the major α, β-unsaturated aldehydes produced during lipid peroxidation, is a potent messenger in mediating signaling pathways. Lipid peroxidation and HNE production appear to increase with aging. Although the cause and effect relation remains arguable, aging is associated with significant changes in diverse signaling events, characterized by enhanced or diminished responses of specific signaling pathways. In this review we will discuss how HNE may contribute to aging-related alterations of signaling pathways.<br /> (Copyright © 2017 Elsevier Inc. All rights reserved.)
- Subjects :
- AMP-Activated Protein Kinases genetics
AMP-Activated Protein Kinases metabolism
Aging genetics
Animals
Cytokines genetics
Cytokines metabolism
Humans
I-kappa B Kinase genetics
I-kappa B Kinase metabolism
Lipid Peroxidation
NF-E2-Related Factor 2 genetics
NF-E2-Related Factor 2 metabolism
NF-kappa B genetics
NF-kappa B metabolism
Oxidative Stress
Proto-Oncogene Proteins c-akt genetics
Proto-Oncogene Proteins c-akt metabolism
TOR Serine-Threonine Kinases genetics
TOR Serine-Threonine Kinases metabolism
Aging metabolism
Aldehydes metabolism
Gene Expression Regulation
Signal Transduction
Subjects
Details
- Language :
- English
- ISSN :
- 1873-4596
- Volume :
- 111
- Database :
- MEDLINE
- Journal :
- Free radical biology & medicine
- Publication Type :
- Academic Journal
- Accession number :
- 27876535
- Full Text :
- https://doi.org/10.1016/j.freeradbiomed.2016.11.032