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Ocimum gratissmum aqueous extract reduces plasma lipid in hypercholesterol-fed hamsters.
- Source :
-
International journal of medical sciences [Int J Med Sci] 2016 Oct 18; Vol. 13 (11), pp. 819-824. Date of Electronic Publication: 2016 Oct 18 (Print Publication: 2016). - Publication Year :
- 2016
-
Abstract
- Objectives: Hyperlipidemia is a significant risk factor in the development of atherosclerosis and related diseases which are major health problem in many developed and developing countries that can lead to fatality due to the changes in lifestyle and dietary habits in this modern age. Methods: In the present study, the Ocimum gratissimum aqueous extract (OGE) was tested for the lowering effect on the serum lipid level of male hamsters on a high-fat (12%) and high-cholesterol (0.2%) diet (HFCD). Results: The results showed that the levels of serum high-density-lipoprotein-cholesterol (HDL-C) low-density-lipoprotein-cholesterol (LDL-C), total cholesterol (TC), and triglycerols (TG) were increased in the HFCD group (113±11, 259±87, 629±175 and 625±262, respectively), as compared to the control normal diet group (51±8, 19±5, 77±16 and 101±44, respectively). When co-treated with various doses (10 and 20 mg/kg) of the OGE or rosuvastatin, the rats exhibited the restoration of normal serum LDL-C, TC, and TG levels. Conclusion: Therefore, we suggest that the Ocimum gratissimum aqueous extract may have the potential function of lowering serum lipid in rats.<br />Competing Interests: The authors have declared that no competing interest exists.
- Subjects :
- Animals
Anticholesteremic Agents administration & dosage
Cholesterol, HDL blood
Cholesterol, LDL blood
Cricetinae
Diet, High-Fat adverse effects
Disease Models, Animal
Hyperlipidemias blood
Liver pathology
Male
Mesocricetus
Plant Extracts administration & dosage
Rats
Rosuvastatin Calcium administration & dosage
Rosuvastatin Calcium therapeutic use
Water
Anticholesteremic Agents therapeutic use
Cholesterol, HDL drug effects
Cholesterol, LDL drug effects
Hyperlipidemias drug therapy
Ocimum chemistry
Plant Extracts therapeutic use
Triglycerides blood
Subjects
Details
- Language :
- English
- ISSN :
- 1449-1907
- Volume :
- 13
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- International journal of medical sciences
- Publication Type :
- Academic Journal
- Accession number :
- 27877073
- Full Text :
- https://doi.org/10.7150/ijms.16474