Back to Search Start Over

Vertebrate embryos as tools for anti-angiogenic drug screening and function.

Authors :
Beedie SL
Diamond AJ
Fraga LR
Figg WD
Vargesson N
Source :
Reproductive toxicology (Elmsford, N.Y.) [Reprod Toxicol] 2017 Jun; Vol. 70, pp. 49-59. Date of Electronic Publication: 2016 Nov 22.
Publication Year :
2017

Abstract

The development of new angiogenic inhibitors highlights a need for robust screening assays that adequately capture the complexity of vessel formation, and allow for the quantitative evaluation of the teratogenicity of new anti-angiogenic agents. This review discusses the use of screening assays in vertebrate embryos, specifically focusing upon chicken and zebrafish embryos, for the detection of anti-angiogenic agents.<br /> (Copyright © 2016 Elsevier Inc. All rights reserved.)

Subjects

Subjects :
Animals
Embryo, Mammalian blood supply
Embryo, Nonmammalian blood supply
Humans
Models, Animal
Angiogenesis Inhibitors pharmacology
Drug Evaluation, Preclinical methods
Embryo, Mammalian drug effects
Embryo, Nonmammalian drug effects
Neovascularization, Physiologic drug effects

Details

Language :
English
ISSN :
1873-1708
Volume :
70
Database :
MEDLINE
Journal :
Reproductive toxicology (Elmsford, N.Y.)
Publication Type :
Academic Journal
Accession number :
27888069
Full Text :
https://doi.org/10.1016/j.reprotox.2016.11.013
Full Text Access
View/download PDF

Tools

Authors Abstract Subjects Details