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Seronegative arthritis associated with serological evidence of Yersinia infection in Australia.
Seronegative arthritis associated with serological evidence of Yersinia infection in Australia.
- Source :
-
Australian and New Zealand journal of medicine [Aust N Z J Med] 1989 Aug; Vol. 19 (4), pp. 331-3. - Publication Year :
- 1989
-
Abstract
- Infection due to yersinia enterocolitica is a common antecedent illness in patients with reactive arthritis in Scandinavia, but appears to be less frequent in other countries. In order to examine the frequency of yersinia infection in patients with seronegative arthritis in Australia we examined 22 patients, 15 with ankylosing spondylitis (AS) and seven with Reiter's syndrome (RS). A sensitive ELISA assay was used to detect serum antibodies to the most common serotypes. Six patients (29%) had positive yersinia serology, all were HLA B27 and four had a history of diarrhea preceding the onset of their disease. Four patients with positive yersinia serology had AS and two had RS. Antibodies were directed against Y. enterocolitica biotype 0:3 in three cases, Y. enterocolitica 0:9 in two cases and Y. enterocolitica 0:8 in one subject. Twenty-nine control subjects (13 HLA B27) had no serum antibodies to yersinia. The results of this study indicate that preceding yersinia infection occurs in a significant (p less than 0.05; compared to controls) proportion of patients with HLA B27 related seronegative arthropathies.
- Subjects :
- Adult
Arthritis etiology
Arthritis, Reactive etiology
Arthritis, Reactive immunology
Australia
Enzyme-Linked Immunosorbent Assay
Female
HLA-B Antigens immunology
HLA-B27 Antigen
Humans
Male
Middle Aged
Retrospective Studies
Spondylitis, Ankylosing etiology
Spondylitis, Ankylosing immunology
Yersinia Infections complications
Yersinia enterocolitica immunology
Antibodies, Bacterial analysis
Arthritis immunology
Yersinia Infections immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0004-8291
- Volume :
- 19
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Australian and New Zealand journal of medicine
- Publication Type :
- Academic Journal
- Accession number :
- 2789509
- Full Text :
- https://doi.org/10.1111/j.1445-5994.1989.tb00274.x