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The unconventional G-protein cycle of LRRK2 and Roco proteins.

Authors :
Terheyden S
Nederveen-Schippers LM
Kortholt A
Source :
Biochemical Society transactions [Biochem Soc Trans] 2016 Dec 15; Vol. 44 (6), pp. 1611-1616.
Publication Year :
2016

Abstract

Mutations in the human leucine-rich repeat kinase 2 (LRRK2) are the most frequent cause of hereditary Parkinson's disease (PD). LRRK2 belongs to the Roco family of proteins, which are characterized by the presence of a Ras of complex proteins domain (Roc), a C-terminal of Roc domain (COR) and a kinase domain. Despite intensive research, much remains unknown about activity and the effect of PD-associated mutations. Recent biochemical and structural studies suggest that LRRK2 and Roco proteins are noncanonical G-proteins that do not depend on guanine nucleotide exchange factors or GTPase-activating proteins for activation. In this review, we will discuss the unusual G-protein cycle of LRRK2 in the context of the complex intramolecular LRRK2 activation mechanism.<br /> (© 2016 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society.)

Details

Language :
English
ISSN :
1470-8752
Volume :
44
Issue :
6
Database :
MEDLINE
Journal :
Biochemical Society transactions
Publication Type :
Academic Journal
Accession number :
27913669
Full Text :
https://doi.org/10.1042/BST20160224