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Tectal-derived interneurons contribute to phasic and tonic inhibition in the visual thalamus.
- Source :
-
Nature communications [Nat Commun] 2016 Dec 08; Vol. 7, pp. 13579. Date of Electronic Publication: 2016 Dec 08. - Publication Year :
- 2016
-
Abstract
- The release of GABA from local interneurons in the dorsal lateral geniculate nucleus (dLGN-INs) provides inhibitory control during visual processing within the thalamus. It is commonly assumed that this important class of interneurons originates from within the thalamic complex, but we now show that during early postnatal development Sox14/Otx2-expressing precursor cells migrate from the dorsal midbrain to generate dLGN-INs. The unexpected extra-diencephalic origin of dLGN-INs sets them apart from GABAergic neurons of the reticular thalamic nucleus. Using optogenetics we show that at increased firing rates tectal-derived dLGN-INs generate a powerful form of tonic inhibition that regulates the gain of thalamic relay neurons through recruitment of extrasynaptic high-affinity GABA <subscript>A</subscript> receptors. Therefore, by revising the conventional view of thalamic interneuron ontogeny we demonstrate how a previously unappreciated mesencephalic population controls thalamic relay neuron excitability.
- Subjects :
- Animals
Biomarkers metabolism
Cell Lineage
Cell Movement
Geniculate Bodies cytology
Male
Mice, Inbred C57BL
Otx Transcription Factors metabolism
SOXB2 Transcription Factors metabolism
Stem Cells metabolism
gamma-Aminobutyric Acid metabolism
Interneurons physiology
Neural Inhibition physiology
Superior Colliculi physiology
Thalamus physiology
Visual Pathways physiology
Subjects
Details
- Language :
- English
- ISSN :
- 2041-1723
- Volume :
- 7
- Database :
- MEDLINE
- Journal :
- Nature communications
- Publication Type :
- Academic Journal
- Accession number :
- 27929058
- Full Text :
- https://doi.org/10.1038/ncomms13579