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Peptide vaccines in cancer-old concept revisited.
- Source :
-
Current opinion in immunology [Curr Opin Immunol] 2017 Apr; Vol. 45, pp. 1-7. Date of Electronic Publication: 2016 Dec 09. - Publication Year :
- 2017
-
Abstract
- Synthetic peptide vaccines aim to elicit and expand tumor-specific T cells capable of controlling or eradicating the tumor. Despite the high expectations based on preclinical studies, the results of clinical trials using peptide vaccines have been disappointing. Thus, many researchers in the field have considered peptide vaccines as outdated and no longer viable for cancer therapy. However, recent progress in understanding the critical roles of immune adjuvants, modes of vaccine administration and T cell dynamics has lead to a rebirth of this approach and reconsidering the use of peptide vaccines for treating malignant disorders.<br /> (Copyright © 2016 Elsevier Ltd. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1879-0372
- Volume :
- 45
- Database :
- MEDLINE
- Journal :
- Current opinion in immunology
- Publication Type :
- Academic Journal
- Accession number :
- 27940327
- Full Text :
- https://doi.org/10.1016/j.coi.2016.11.001