Biopsy of the sentinel node in lung cancer.

Authors :: Uribe-Etxebarria Lugariza-Aresti N
Barceló Galíndez R
Pac Ferrer J
Méndez Martín J
Genollá Subirats J
Casanova Viudez J
Source :: Medicina clinica [Med Clin (Barc)] 2017 Mar 22; Vol. 148 (6), pp. 257-259. Date of Electronic Publication: 2016 Dec 16.
Publication Year :: 2017
Abstract: Introduction and Objective: Mediastinal lymph node involvement can be understaged in cases of lung cancer (up to 20% in stage i). Sentinel node detection is a standard technique recommended in breast cancer and melanoma action guidelines, and could also be useful in cases of lung cancer.<br />Material and Methods: Considering the detection of the sentinel node in non-small cell lung cancer (NSCLC) as feasible, a prospective cohort study was carried out on 48 patients with resectable NSCLC, using the intraoperative injection of colloid sulphate technetium-99.<br />Results: The radioisotope migrated in all cases. The procedure's sensitivity was 88.24%, its accuracy was 95.83%, its negative predictive value was 93.94% and the false negative rate was 11.76%. No complications were associated with this technique.<br />Conclusions: The detection of a sentinel node in NSCLC with the intraoperative injection of the isotope is feasible and safe, and allows for detection and sensitivity rates comparable to those of other tumour types.<br /> (Copyright © 2016 Elsevier España, S.L.U. All rights reserved.)