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Comparison of cerebrospinal fluid profiles in Alzheimer's disease with multiple cerebral microbleeds and cerebral amyloid angiopathy-related inflammation.
- Source :
-
Journal of neurology [J Neurol] 2017 Feb; Vol. 264 (2), pp. 373-381. Date of Electronic Publication: 2016 Dec 20. - Publication Year :
- 2017
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Abstract
- Brain magnetic resonance imaging (MRI) of patients with Alzheimer's disease (AD) sometimes reveals multiple cerebral microbleeds (CMBs) and confluent white matter hyperintensities (WMHs) similar to those observed in cerebral amyloid angiopathy-related inflammation (CAA-I). To determine whether there might be common pathophysiological mechanisms underlying the MRI findings of multiple CMBs and confluent WMHs, we investigated the cerebrospinal fluid (CSF) profiles of 38 AD, five amnestic mild cognitive impairment (MCI), and six CAA-I patients. The AD and MCI patients were divided into groups of patients with (n = 10) or without (n = 33) multiple CMBs (n ≥ 2) on T2*-gradient echo sequences of brain MRI. We compared the CSF profiles of AD and MCI patients with or without multiple CMBs, and CAA-I patients. The brain MRIs of the patients with multiple CMBs revealed severe degrees of WMHs compared with the patients without multiple CMBs. The levels of CSF anti-amyloid β autoantibody and interleukin 8, and CSF/serum albumin ratios and immunoglobulin G indexes, were significantly higher in CAA-I patients than the other groups. However, there were no significant differences in the CSF profiles of patients with or without multiple CMBs. Our study provides evidence for different pathophysiological mechanisms underlying these differential MRI findings in AD and CAA-I.
- Subjects :
- Aged
Alzheimer Disease complications
Alzheimer Disease diagnostic imaging
Alzheimer Disease immunology
Amyloid beta-Peptides immunology
Atherosclerosis cerebrospinal fluid
Atherosclerosis complications
Atherosclerosis immunology
Autoantibodies cerebrospinal fluid
Biomarkers cerebrospinal fluid
Brain immunology
Cerebral Amyloid Angiopathy complications
Cerebral Amyloid Angiopathy diagnostic imaging
Cerebral Amyloid Angiopathy immunology
Cerebral Hemorrhage complications
Cerebral Hemorrhage diagnostic imaging
Cerebral Hemorrhage immunology
Cognitive Dysfunction complications
Cognitive Dysfunction diagnostic imaging
Cognitive Dysfunction immunology
Female
Humans
Magnetic Resonance Imaging
Male
Risk Factors
Spinal Puncture
White Matter diagnostic imaging
White Matter immunology
Alzheimer Disease cerebrospinal fluid
Brain diagnostic imaging
Cerebral Amyloid Angiopathy cerebrospinal fluid
Cerebral Hemorrhage cerebrospinal fluid
Cognitive Dysfunction cerebrospinal fluid
Subjects
Details
- Language :
- English
- ISSN :
- 1432-1459
- Volume :
- 264
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of neurology
- Publication Type :
- Academic Journal
- Accession number :
- 28000005
- Full Text :
- https://doi.org/10.1007/s00415-016-8362-2