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Efficacy and Safety of Insulin Therapy in Patients with Type 2 Diabetes Treated at Different Grades of Hospitals in China: Subgroup Analysis of the Real-World SEAS Study.
- Source :
-
Diabetes technology & therapeutics [Diabetes Technol Ther] 2017 Jan; Vol. 19 (1), pp. 34-40. Date of Electronic Publication: 2016 Dec 21. - Publication Year :
- 2017
-
Abstract
- Backgrounds: As patients attending hospitals of different grades in China may receive different medical care, we investigated the clinical efficacy and safety of routine insulin therapy in patients with type 2 diabetes who were treated at grade 2 and grade 3 (highest grade) hospitals in China.<br />Methods: 2683 patients with type 2 diabetes were enrolled in a multicenter, nonrandomized, open-label, noninterventional, 12-week clinical trial performed at 62 Chinese hospitals. Patients were divided into two groups according to the hospitals' grading. Data were analyzed for efficacy (changes and normalization of glycated hemoglobin [HbA1c] and changes in fasting plasma glucose and 2-h postprandial blood glucose [PBG] levels from baseline to the final visit) and for safety (hypoglycemia).<br />Results: After 12 weeks of routine human insulin (SciLin) therapy, decreases in mean HbA1c and PBG levels were significantly greater in patients treated at second-grade hospitals (all P < 0.001 vs. third-grade hospitals), and the HbA1c success rate (<7%) was significantly higher (46.94% vs. 38.85%; P = 0.0002). However, patients treated at second-grade hospitals had more weight gain (0.29 kg vs. 0.04 kg; P < 0.0001) and a higher incidence of total hypoglycemic events (21.82% vs. 16.79%; P = 0.0002).<br />Conclusions: Routine insulin treatment of patients with type 2 diabetes in China demonstrates acceptable safety and effectiveness, improving blood glucose control with a low incidence of severe hypoglycemia. Patients treated at second-grade hospitals had a greater HbA1c success rate than those treated at third-grade hospitals, but with more weight gain and more hypoglycemic events.
- Subjects :
- Adult
Aged
China
Female
Glycated Hemoglobin analysis
Hospitals
Humans
Hypoglycemic Agents adverse effects
Insulin adverse effects
Male
Middle Aged
Postprandial Period
Treatment Outcome
Blood Glucose analysis
Diabetes Mellitus, Type 2 drug therapy
Hypoglycemia chemically induced
Hypoglycemic Agents therapeutic use
Insulin therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1557-8593
- Volume :
- 19
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Diabetes technology & therapeutics
- Publication Type :
- Academic Journal
- Accession number :
- 28001434
- Full Text :
- https://doi.org/10.1089/dia.2016.0305