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White matter microstructure and volitional motor activity in schizophrenia: A diffusion kurtosis imaging study.
- Source :
-
Psychiatry research. Neuroimaging [Psychiatry Res Neuroimaging] 2017 Feb 28; Vol. 260, pp. 29-36. Date of Electronic Publication: 2016 Oct 15. - Publication Year :
- 2017
-
Abstract
- Avolition is a core feature of schizophrenia and may arise from altered brain connectivity. Here we used diffusion kurtosis imaging (DKI) to investigate the association between white matter (WM) microstructure and volitional motor activity. Multi-shell diffusion MRI and 24-h actigraphy data were obtained from 20 right-handed patients with schizophrenia and 16 right-handed age and gender matched healthy controls. We examined correlations between fractional anisotropy (FA), mean diffusivity (MD), mean kurtosis (MK), and motor activity level, as well as group differences in these measures. In the patient group, increasing motor activity level was positively correlated with MK in the inferior, medial and superior longitudinal fasciculus, the corpus callosum, the posterior fronto-occipital fasciculus and the posterior cingulum. This association was not found in control subjects or in DTI measures. These results show that a lack of volitional motor activity in schizophrenia is associated with potentially altered WM microstructure in posterior brain regions associated with cognitive function and motivation. This could reflect both illness related dysconnectivity which through altered cognition, manifests as reduced volitional motor activity, and/or the effects of reduced physical activity on brain WM.<br /> (Copyright © 2016. Published by Elsevier B.V.)
- Subjects :
- Adult
Anisotropy
Brain physiopathology
Brain Mapping methods
Diffusion Magnetic Resonance Imaging
Diffusion Tensor Imaging methods
Female
Humans
Male
Middle Aged
Schizophrenia physiopathology
Young Adult
Brain diagnostic imaging
Motor Activity physiology
Schizophrenia diagnostic imaging
White Matter diagnostic imaging
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7506
- Volume :
- 260
- Database :
- MEDLINE
- Journal :
- Psychiatry research. Neuroimaging
- Publication Type :
- Academic Journal
- Accession number :
- 28012424
- Full Text :
- https://doi.org/10.1016/j.pscychresns.2016.10.002