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Development and Structural Modification of BACE1 Inhibitors.
- Source :
-
Molecules (Basel, Switzerland) [Molecules] 2016 Dec 22; Vol. 22 (1). Date of Electronic Publication: 2016 Dec 22. - Publication Year :
- 2016
-
Abstract
- Alzheimer's disease (AD) is a progressive neurodegenerative disorder which usually occurs in the elderly. The accumulation of β-amyloid and the formation of neurofibrillary tangles are considered as the main pathogenies of AD. Research suggests that β-secretase 1 (BACE1) plays an important role in the formation of β-amyloid. Discovery of new BACE1 inhibitors has become a significant method to slow down the progression of AD or even cure this kind of disease. This review summarizes the different types and the structural modification of these new BACE1 inhibitors.
- Subjects :
- Alkaloids chemical synthesis
Alkaloids pharmacology
Alzheimer Disease metabolism
Alzheimer Disease pathology
Amyloid Precursor Protein Secretases biosynthesis
Amyloid Precursor Protein Secretases genetics
Amyloid beta-Peptides antagonists & inhibitors
Amyloid beta-Peptides biosynthesis
Amyloid beta-Peptides genetics
Aspartic Acid chemistry
Aspartic Acid metabolism
Aspartic Acid Endopeptidases biosynthesis
Aspartic Acid Endopeptidases genetics
Curcumin chemical synthesis
Curcumin pharmacology
Enzyme Inhibitors pharmacology
Gene Expression
Humans
Hydrophobic and Hydrophilic Interactions
Neuroprotective Agents pharmacology
Peptidomimetics pharmacology
Piperazines chemical synthesis
Piperazines pharmacology
Structure-Activity Relationship
Terpenes chemical synthesis
Terpenes pharmacology
Alzheimer Disease drug therapy
Amyloid Precursor Protein Secretases antagonists & inhibitors
Aspartic Acid Endopeptidases antagonists & inhibitors
Enzyme Inhibitors chemical synthesis
Neuroprotective Agents chemical synthesis
Peptidomimetics chemical synthesis
Subjects
Details
- Language :
- English
- ISSN :
- 1420-3049
- Volume :
- 22
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Molecules (Basel, Switzerland)
- Publication Type :
- Academic Journal
- Accession number :
- 28025519
- Full Text :
- https://doi.org/10.3390/molecules22010004