Back to Search
Start Over
Predictive value of MRI features for development of radiographic osteoarthritis in a cohort of participants with pre-radiographic knee osteoarthritis-the CHECK study.
- Source :
-
Rheumatology (Oxford, England) [Rheumatology (Oxford)] 2017 Jan; Vol. 56 (1), pp. 113-120. Date of Electronic Publication: 2016 Oct 25. - Publication Year :
- 2017
-
Abstract
- Objective: To determine whether MRI features are associated with development of radiographic knee OA and can be used as a predictive tool in early knee OA.<br />Methods: In 148 participants of the Cohort Hip and Cohort Knee study (mean age 56 years, 78% women), with a Kellgren Lawrence (KL) score ⩽1, we obtained semi-quantitatively scored knee MRI scans and radiographs at baseline. After 5 years, we determined the development of radiographic knee OA (KL ⩾2). We calculated odds ratios (ORs), with 95% CIs adjusted for age, sex and BMI, to identify MRI features associated with OA development. With these MRI features, we constructed an internally validated prediction model, for which we measured the area under the receiver operating characteristics curve, sensitivity and specificity.<br />Results: Radiographic OA developed in 28% of the participants after 5 years. Statistically significant associations were: cartilage defects OR = 1.7 (95% CI: 1.1, 2.6), osteophytes OR = 3.1 (1.7, 5.7), bone marrow lesions OR = 2.0 (1.2, 3.4), effusion OR = 2.1 (1.2, 3.5) and meniscal pathology OR = 2.8 (1.3, 6.3). With the combined MRI features in a prediction model, the sensitivity was 66%, the specificity 67% and the optimism-corrected area under the receiver operating characteristics curve 0.685.<br />Conclusion: In early knee OA, MRI depicts significantly associated pathology in cartilage, bone and menisci, whereas the radiograph fails to detect these changes. Although MRI has potential for identifying patients at risk for developing radiographic knee OA, it cannot be used as an absolute diagnostic tool in early knee OA due to its low discriminative ability.<br /> (© The Author 2016. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oup.com.)
- Subjects :
- Aged
Cohort Studies
Disease Progression
Female
Follow-Up Studies
Humans
Longitudinal Studies
Magnetic Resonance Imaging
Male
Middle Aged
Odds Ratio
Prognosis
ROC Curve
Radiography
Risk Assessment
Bone Marrow diagnostic imaging
Cartilage, Articular diagnostic imaging
Knee Joint diagnostic imaging
Menisci, Tibial diagnostic imaging
Osteoarthritis, Knee diagnostic imaging
Osteophyte diagnostic imaging
Subjects
Details
- Language :
- English
- ISSN :
- 1462-0332
- Volume :
- 56
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Rheumatology (Oxford, England)
- Publication Type :
- Academic Journal
- Accession number :
- 28028160
- Full Text :
- https://doi.org/10.1093/rheumatology/kew368