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Heat shock proteins HSP90, HSP70 and GRP78 expression in medullary thyroid carcinoma.
- Source :
-
Annals of diagnostic pathology [Ann Diagn Pathol] 2017 Feb; Vol. 26, pp. 52-56. Date of Electronic Publication: 2016 Nov 30. - Publication Year :
- 2017
-
Abstract
- Background: Medullary thyroid carcinoma management consists mainly of surgical resection and is largely chemoresistant. There is ongoing effort to discover novel therapies for medullary thyroid carcinoma. Increased levels of heat shock proteins have been associated with multiple cancers and are being studied as potential therapeutic targets. The purpose of this study was to determine the expression levels of heat shock proteins 90 and 70 and of glucose related protein 78 in medullary thyroid carcinoma tissues compared with normal thyroid tissues.<br />Methods: 20 tissue specimens of medullary thyroid carcinoma and 10 specimens of thyroids without malignancy were analyzed by immunohistochemistry.<br />Results: Medullary thyroid carcinoma specimens showed 27% higher expression level of heat shock protein 90 immunostaining, and a 43% higher expression level of heat shock protein 70 immunostaining versus normal controls. These differences, however, were not statistically significant. A significantly higher expression level was noted for glucose related protein 78 in the medullary thyroid carcinoma specimens than in the controls.<br />Conclusion: This study indicates increased expression levels of heat shock proteins 90 and 70 and glucose related protein 78 levels in medullary thyroid carcinoma. These findings, though preliminary imply that these proteins may have a role in medullary thyroid carcinoma's tumor biology and may have and future therapeutic options. Larger cohorts are needed to corroborate these results.<br /> (Copyright © 2016 Elsevier Inc. All rights reserved.)
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Carcinoma, Neuroendocrine diagnosis
Carcinoma, Neuroendocrine pathology
Child
Endoplasmic Reticulum Chaperone BiP
Female
Humans
Immunohistochemistry methods
Male
Middle Aged
Thyroid Neoplasms diagnosis
Thyroid Neoplasms pathology
Young Adult
Carcinoma, Neuroendocrine metabolism
HSP70 Heat-Shock Proteins metabolism
HSP90 Heat-Shock Proteins metabolism
Heat-Shock Proteins metabolism
Thyroid Neoplasms metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1532-8198
- Volume :
- 26
- Database :
- MEDLINE
- Journal :
- Annals of diagnostic pathology
- Publication Type :
- Academic Journal
- Accession number :
- 28038712
- Full Text :
- https://doi.org/10.1016/j.anndiagpath.2016.11.003