Topical ivermectin improves allergic skin inflammation.

Authors :: Ventre E
Rozières A
Lenief V
Albert F
Rossio P
Laoubi L
Dombrowicz D
Staels B
Ulmann L
Julia V
Vial E
Jomard A
Hacini-Rachinel F
Nicolas JF
Vocanson M
Source :: Allergy [Allergy] 2017 Aug; Vol. 72 (8), pp. 1212-1221. Date of Electronic Publication: 2017 Feb 06.
Publication Year :: 2017
Abstract: Background: Ivermectin (IVM) is widely used in both human and veterinary medicine to treat parasitic infections. Recent reports have suggested that IVM could also have anti-inflammatory properties.<br />Methods: Here, we investigated the activity of IVM in a murine model of atopic dermatitis (AD) induced by repeated exposure to the allergen Dermatophagoides farinae, and in standard cellular immunological assays.<br />Results: Our results show that topical IVM improved allergic skin inflammation by reducing the priming and activation of allergen-specific T cells, as well as the production of inflammatory cytokines. While IVM had no major impact on the functions of dendritic cells in vivo and in vitro, IVM impaired T-cell activation, proliferation, and cytokine production following polyclonal and antigen-specific stimulation.<br />Conclusion: Altogether, our results show that IVM is endowed with topical anti-inflammatory properties that could have important applications for the treatment of T-cell-mediated skin inflammatory diseases.<br /> (© 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)